超声双重造影对进展期胃癌化疗疗效评价的初步研究

Evaluation of the chemotherapy effect in advanced gastric carcinoma using double contrast-enhanced ultrasonography

目的 探讨超声双重造影在进展期胃癌化疗疗效评价中的应用价值.方法 对21例不能手术切除并接受化疗的进展期胃痛患者,在化疗前、后行口服胃窗造影及静脉超声造影（即超声双重造影）检查,并将化疗前、后超声造影结果进行比较.结果 与化疗前比较,化疗后病灶厚度稍变薄,但差异无统计学意义（P＞0.05）,化疗后胃癌组织的基础强度（BI）、峰值强度（PI）、造影剂到达时间（AT）及达峰时间（TTP）差异均无统计学意义（P＞0.05）.而化疗后胃癌组织增强强度（EI）值明显降低,与化疗前比较差异具有统计学意义（P＜0.05）.结论 胃癌组织EI值可作为评价进展期胃癌化疗疗效的一项敏感、有效指标.

Objective To explore the clinical value of double contrast-enhanced ultrasonography （DCUS） on evaluation of the chemotherapy effect in advanced gastric carcinoma. Methods A total of 21 patients with unresectable and received chemotherapy of advanced gastric carcinoma were examined using ultrasound after taking oral contrast agent and bolus injection of Sono Vue, and findings of DCUS of each patient before and after chemotherapy were compared. Results The thickness of lesions was slightly thinner than that after chemotherapy,but there was no significant difference （ P ＞0. 05）. In addition, there was no significant difference in the basal intensity （BI）, peak intensity （PI）, arrive time （AT） and time to peak （TTP） of gastric carcinoma tissues after chemotherapy （P ＞0.05）. While the enhanced intensity （EI） value of gastric carcinoma tissues after chemotherapy was significantly less than that before chemotherapy （P ＜0.05）. Conclusions The EI value in gastric carcinoma tissues may be considered as a sensitive and effective index in assessing the therapeutic effect of the chemotherapy in patients with advanced gastric carcinoma.