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2型糖尿病的全基因组关联研究 被引量：4

Genome-wide association studies of type 2 diabetes mellitus
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摘要 近年来,全基因组关联研究在复杂疾病遗传学方面取得了巨大成功.作为一种典型的复杂疾病,2型糖尿病也是重要的研究热点.本文就全基因组关联研究及其在2型糖尿病的应用进行综述. Abstract：Recently, genome-wide association study （GWAS）has achieved great success in illuminating genetic basis of complex diseases. GWAS of type 2 diabetes is regarded as a paradigm of genetic dissection of complex human diseases, which are caused by both genetic and environmental factors. Some basic facts of GWAS,as well as implementation of GWAS in type 2 diabetes, are reviewed in this article.
作者 朱啸 林宁光
机构地区 上海交通大学医学院附属瑞金医院内分泌代谢病科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2010年第12期1094-1096,共3页 Chinese Journal of Endocrinology and Metabolism
基金 863计划（2006AA02A409）,国家自然基金（30800536）
关键词 全基因组关联研究 精尿病 2型 遗传化电 Genome-wide association study Diabetes mellitus, type 2 Genetic locus
分类号 R587.1 [医药卫生—内分泌]
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参考文献27

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同被引文献43

  • 1张明,田林红.白细胞介素6受体基因单核苷酸多态性与2型糖尿病的关联性[J].中华医学遗传学杂志,2006,23(6):662-664. 被引量：6
  • 2Simmonds M J, Howson JM, Heward JM, et al. A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA- DRB1 effect. Hum Mol Genet, 2007,16:2149-2153.
  • 3Jacobson EM, Huber A, Tomer Y. The HLA gene complex in thyroid autoimmunity: from epidemiology to etiology. J Autoimmun, 2008,30: 58-62.
  • 4Ueda H, Howson JM, Esposito L, et al. Association of the T-cell regulatory" gene CTLA4 with susceptibility to autoimmune disease. Nature, 2003,423:506-511.
  • 5Heward JM, Brand O J, Barrett JC, et al. Association of PTPN22 haplotypes with Graves' disease. J Clin Endocrinol Metab, 2007,92: 685-590.
  • 6Brand OJ, Barrett JC, Simmonds M J, et al. Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Hum Mol Genet, 2009,18 : 1704-1713.
  • 7Brix TFI, Kyvik KO, Christensen K, et al. Evidence for a major role of heredity in Graves' disease : a population-based study of two Danish twin cohorts. J Clin Endocrinol Metab, 2001,86:930-934.
  • 8Sachidanandam R, Weissman D, Schmidt SC, et al. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature, 2001,409:928-933.
  • 9Saxena R, Voight BF, Lyssenko V, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science, 2007,316 : 1331-1336.
  • 10Harley JB, Alarc6n-Riquehne ME, Criswell LA, et al. Genome-wide association scan in women with systemic lupus ethematosus identifies susceptibility variants in ITGAM, PXK, KIAAI542 and other loci. Nat Genet, 2008,40:204-210.

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中华内分泌代谢杂志
2010年 第12期

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