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奥美拉唑和泮托拉唑预防急性冠脉综合征患者抗血小板治疗致消化道出血355例 被引量:4

Omeprazole or pantoprazole prevent gastrointestinal bleeding caused by antiplatelet therapy in 355 patients with acute coronary syndrome
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摘要 目的回顾性分析奥美拉唑和泮托拉唑预防急性冠脉综合征患者应用阿司匹林或氯吡格雷治疗所致消化道出血的有效性和安全性。方法 355例急性冠脉综合征患者,初始治疗给予口服氯吡格雷300 mg和阿司匹林300 mg一次;d 2起分为泮托拉唑(40 mg.d-1)+氯吡格雷(75 mg.d-1)组(CP组)120例、奥美拉唑(20 mg.d-1)+氯吡格雷(75 mg.d-1)组(CO组)115例、奥美拉唑(20 mg.d-1)+阿司匹林(100 mg.d-1)组(AO组)120例,po,qd。3组均同时口服枸橼酸铋钾300 mg,tid和阿托伐他汀20 mg,qd。治疗48 wk,观察3组患者心血管一级终点事件和消化道出血事件,及治疗期间肝、肾功能变化。结果 CP组发生一级终点事件12例(10.0%),CO组23例(20.0%),AO组11例(9.2%);CP组与AO组无显著差异(P>0.05),且均显著低于CO组(P<0.05)。CP组消化道出血8例(6.7%),CO组17例(14.8%),AO组18例(15.0%);CO组与AO组无显著差异(P>0.05),且均显著高于CP组(P<0.05)。3组治疗前后肝、肾功能差异无统计学意义。结论奥美拉唑和泮托拉唑均能安全有效地预防急性冠脉综合征患者应用阿司匹林或氯吡格雷治疗所致的消化道出血,泮托拉唑优于奥美拉唑。 AIM To study the efficacy and safety of omeprazole or pantoprazole on preventing hemorrhage of alimentary tract caused by antiplatelet therapy in patients with acute coronary syndrome.METHODS The 355 patients with acute coronary syndrome were divided into clopidogrel plus pantoprazole group(CP group,n = 120),clopidogrel plus omeprazole group(CO group,n = 115)and aspirin plus omeprazole group(AO group,n = 115)after initial treatment with oral clopidogrel 300 mg and aspirin 300 mg once.The three groups were treated with clopidogrel 75 mg plus pantoprazole 40 mg,clopidogrel 75 mg plus omeprazole 20 mg,or aspirin 100 mg plus omeprazole 20 mg,po,qd,respectively.On the base of routine therapy all patients accepted bismuth potassium citrate 300 mg,po,tid,and atorvastatin 20 mg,po,qd.The liver and renal function and the incidence of gastrointestinal bleedings and cardiovascular events were observed among the three groups.RESULTS The incidence of cardiovascular events in CP group(12 patients,10.0%)and AO group(11 patients,9.2%)was significantly lower than that of CO group(23 patients,20.0%)(P 0.05).The incidence of gastrointestinal bleeding in CO group(17 patients,14.8%)was significantly higher than that of CP group(8 patients,6.7%)(P 0.05)and was similar with that of AO group(18 patients,15.0%).There were no statistic differences of liver and renal functions in three groups before and after the treatment(P 0.05).CONCLUSION Omeprazole and pantoprazole could effectively prevent gastrointestinal bleeding caused by antiplatelet therapy in patients with acute coronary syndrome,and pantoprazole effects much more markedly than omeprazole.
作者 刘维太
机构地区 淮安市楚州医院
出处 《中国新药与临床杂志》 CAS CSCD 北大核心 2010年第12期904-907,共4页 Chinese Journal of New Drugs and Clinical Remedies
关键词 急性冠脉综合征 血小板聚集抑制剂 奥美拉唑 泮托拉唑 氯吡格雷 acute coronary syndrome platelet aggregation inhibitors omeprazole pantoprazole clopidogrel
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  • 1任斌,黎曙霞,洪晓丹,唐蕾,姚秋燕,黄碧莹.80例肾移植患者他克莫司血药浓度数据分析[J].中国药房,2004,15(11):682-683. 被引量:8
  • 2黎友伦,罗永艾.氨茶碱的药理作用与临床应用[J].医药导报,2005,24(9):807-809. 被引量:59
  • 3刘治军,傅得兴,孙春华,迟家敏,张亚同.体内药物相互作用研究进展[J].药物不良反应杂志,2006,8(1):33-38. 被引量:63
  • 4王欧明,宋美芳,周权.某院门诊2003—2005年地高辛合并用药分析[J].中国药业,2006,15(18):43-45. 被引量:5
  • 5韩咏霞.阿卡波糖与地高辛合用需谨慎[N].大众卫生报,2009-09-15(11).
  • 6KUZUYA T, KOBAYASHI T, MORIYAMA N, et al. Amlo- dipine, but not MDR1 pymorphisms, alters the pharmacoki- netics of cyclosporine A in Japanese kidney transplant re- cipients [ J ]. Transplantation,2003,76 ( 5 ) : 865-868.
  • 7XU F,ZHAI S D,HU Y F. The molecular mechanism of the interaction of tacrolimus [ J ]. Chin Pharm J,2007,42 ( 13 ) : 965-1038.
  • 8LEROY S, ISAPOF A, FARGUE S, et al. Tacrolimus neph- rotoxicity : Beware of the association of diarrhea, drug inter- action and pharmacogenetics [ J ]. Pediatr Nephrol, 2010,25 (5) :965-969.
  • 9KHAIRA A, RATHI O P, GUPTA A, et al. Galactorrhoea and mastalgia in a renal transplant recipient on tacrolimus and amlodipine[ J ]. Asia Pac Soc Nephrol, 2009,14 ( 7 ) : 700-701.
  • 10JACQUELINE S, DANIEWE M, STEVEN R, et al. Lack of evidence of a clopidogrel statin interaction in the CHAR IS- MA trial[J]. J Am Coll Cardiol,2007,50(4):291-295.

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