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颗粒细胞和卵泡液因子在评估卵母细胞质量中的价值 被引量：5

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摘要 正确评估卵母细胞的质量对于改善人类辅助生殖技术的治疗结局有重要意义。卵母细胞的评估方法有多种,其中,颗粒细胞和卵泡液因子在评估卵母细胞质量中的作用备受关注。研究显示颗粒细胞的凋亡率与卵母细胞的发育能力呈负相关;卵泡液中的雌激素水平或雌激素与雄激素(或孕激素)的比率、胰岛素样生长因子(IGF)和胰岛素样生长因子结合蛋白(IGFBP)的表达与卵母细胞的质量有关,而卵泡液中的其他因子,如瘦素、抗苗勒激素等与卵母细胞质量之间的关系尚不明确。卵丘细胞的基因表达、卵泡液因子及代谢组学的进一步研究,有望成为评估卵母细胞质量的重要工具。
作者 张玲 熊承良
机构地区 华中科技大学同济医学院计划生育研究所
出处 《生殖与避孕》 CAS CSCD 北大核心 2010年第12期827-831,共5页 Reproduction and Contraception
关键词 卵母细胞质量 卵泡颗粒细胞 卵泡液
分类号 R714.8 [医药卫生—妇产科学]
  • 相关文献

参考文献35

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二级参考文献17

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共引文献7

同被引文献83

  • 1沈健,冯云.抑制素B在人类配子发生中的意义[J].生殖与避孕,2005,25(6):353-357. 被引量：9
  • 2王妍,赵晓娥,杨培先,张仕强,苏利红,马保华.小鼠卵巢颗粒细胞的体外培养[J].西北农林科技大学学报（自然科学版）,2007,35(8):11-14. 被引量：22
  • 3黄健,郑月慧,徐良全.原始卵泡生长启动调控机制的研究进展[J].生殖医学杂志,2007,16(5):372-376. 被引量：4
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生殖与避孕
2010年 第12期

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