摘要
近年来研究表明,表观遗传修饰的DNA甲基化在结直肠癌的发生发展中具有重要的作用。在结直肠癌中普遍存在DNA甲基化,对于肿瘤的早期诊断具有重要的指导意义。因为DNA甲基化的可逆性,可能为肿瘤的治疗提供靶点。从DNA甲基化方面寻找预测结直肠癌药物疗效的分子标志物,有可能成为推动结直肠癌个体化治疗的新方向。
In recent years,studies have shown that DNA methylation has an important role in the development of colorectal cancer.The prevalence of DNA methylation in colorectal cancer has important guiding significance for early diagnosis of tumor.Because of the reversibility of DNA methylation,it may provide targets for the teatment.Therefore,DNA methlation may become a new field for searching the molecular marker to predict the drug efficacy of colorectal cancer.
出处
《临床肿瘤学杂志》
CAS
2010年第12期1142-1145,共4页
Chinese Clinical Oncology
关键词
结直肠癌
DNA甲基化
CPG岛
诊断
分子标志
Colorectal cancer
DNA methylation
CpG island
Diagnosis
Molecular marker
