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脆性X相关蛋白Ⅰ结构及功能研究进展

Advance in Structure and Function of Fragile X-related 1 Protein Research
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摘要 脆性X相关蛋白Ⅰ(FXR1P)是脆性X蛋白家族成员,与脆性X智力低下蛋白(FMRP)的氨基酸序列60%以上相似。FXR1P分子中存在KH-Ⅰ结构域、RGG结构域、Agenet结构域、NLS、NES信号、NoS等结构;FXR1P可作为转录调节因子参与特定mRNA的转录与翻译。研究表明,FXR1P可以参与miRNA调控途径,实现对靶mRNA的调节。从结构和功能方面对FXR1P研究进展作一综述。 Fragile X-related 1 Protein（FXR1P） is one member of fragile X protein family.FXR1P has high amino acid sequence identity to FMRP（60%）.l FXR1P contains two KH domains、an RGG box 、arginine rich motif、 nuclear localization（NLS） 、 nuclear export（NES） and NoS,FXR1P bind target mRNAs to regulate their translation.Also FXR1P can utilize the miRNA pathway to regulate target mRNA expression.This article mainly reviewed the mlecular structure and the function of FXR1P.
作者 符向辉 何淑雅 李斌元 董晓 马云
机构地区 南华大学生物化学与分子生物学教研室
出处 《微量元素与健康研究》 CAS 2011年第2期55-57,63,共4页 Studies of Trace Elements and Health
基金 国家自然科学基金项目(30370795) 湖南省自然科学基金资助项目(07JJ3030)
关键词 脆性X相关蛋白I 脆性X综合症 miRNA调节途径 FXR1P Fragile X syndrome miRNA pathway
分类号 R394.3 [医药卫生—医学遗传学]
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参考文献20

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二级参考文献24

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微量元素与健康研究
2011年 第2期

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