氮杂环丙烷与腈的[3+2]环加成反应生成咪唑啉的研究进展

Advance in Synthesis of Imidazoline by [3+2]-Cycloaddition of N-tosyl Aziridines with nitriles

咪唑啉是一种非常重要的药物中间体,其通过氮杂环丙烷与腈的[3+2]环加成反应是非常有效合成方法。综述了这种方法的研究进展,并且进行了评价与展望。

Imidazolines are useful intermediates for the preparation of drugs and relevant compounds,which are synthetized by [3＋2]-Cycloaddition of various substituted N-tosyl aziridines with nitriles as a quite efficient method.The research progress of this method was reviewed、evaluated and prospected.