糖通饮对早期糖尿病肾病尿白蛋白/肌酐比值、血液流变学的影响

Effect of Tangtong Yin on Urinary Albumin/Creatinine Ratio and Hemorheology in Patients with Early Diabetic Nephropathy

目的观察经验方糖通饮对尿白蛋白/肌酐比值及血液流变学的影响,探讨该方对早期糖尿病肾病的临床疗效及作用机理。方法 45例2型糖尿病早期肾病患者,随机分成对照组与治疗组,经3个月治疗后,观察尿白蛋白/肌酐比值及血液流变学的变化。结果治疗组与治疗前及与对照组相比,尿白蛋白/肌酐比值,全血低切粘度、高切粘度、血浆粘度、纤维蛋白原均有较显著下降(P<0.01或P<0.05)。结论应用糖通饮能减少早期糖尿病肾病患者尿微量白蛋白排出,降低血粘稠度,改善微循环,对治疗早期糖尿病肾病有较好的疗效。

Objective To observe the effect of Tangtong Yin（TTY） on urinary albumin/creatinine ratio and hemorheology in patients with early diabetic nephropathy（EDN）,and explore its curative effect and mechanism.Methods 45 EDN patients were assigned to control group and TTY group.After 3 months,the changes of urinary albumin/creatinine ratio and hemorheology were observed.Results After the treatment,the urinary albumin/creatinine ratio,whole blood low shear viscosity,high shear viscosity,plasma viscosity and fibrinogen decreased significantly in TTY group,and the decreasing amplitude of the tested indices in TTY group was higher than that of control group（P〈0.01 or P〈0.05）.Conclusion TTY can reduce urinary albumin excretion in EDN patients,decrease blood viscosity,improve microcirculation,and has good effects on EDN.