免疫球蛋白联合激素治疗自身免疫性大疱病

Treatment of autoimmune bullous diseases with combined immunoglobulin and glucocorticoid hormone

目的评价大剂量免疫球蛋白联合糖皮质激素治疗自身免疫性大疱性皮肤病的疗效及不良反应。方法 32例患者使用免疫球蛋白每次0.4g/kg,1次/d,静脉滴注,连续5d,同时联合应用糖皮质激素治疗。结果所有患者均取得明显效果,93.8%的患者2-6d后水疱停止发生,黏膜损害消退,激素用量减少,未发现不良反应。结论大剂量静脉注射免疫球蛋白联合糖皮质激素治疗自身免疫性大疱性皮肤病可缩短病程,减少激素的用量,降低激素不良反应,是一种有效的辅助治疗方法。

Objective To assess the therapeutic effect and adverse reactions of high immunoglobulin dose in combination with glucocorticoid hormone in patients with autoimmune bullous diseases.Methods Thirty-two patients with autoimmune bullous diseases were treated with intravenous immunoglobulin（0.4g/（kg·d）） plus glucorticoid hormone for 5 days.Results Good outcome was achieved in all the patients.No new blister was found and mucosal lesions were disappeared in 93.8% of the patients 2-6 days after treatment with no adverse reaction.Thus,the dose of glucorticoid hormone was reduced.Conclusion High intravenous immunoglobulin dose plus glucorticoid hormone can shorten the treatment course of autoimmune bullous diseases and reduce the adverse reactions to glucorticoid hormone,and is thus an effective adjuvant therapy for autoimmune bullous diseases.