摘要
目的:观察复方丁香罗勒口服混悬液联合消旋卡多曲颗粒治疗婴幼儿轮状病毒性腹泻的临床疗效。方法:将诊断为轮状病毒感染性急性腹泻患儿100例随机分为治疗组和对照组各50例。对照组在常规补液的基础上按年龄服用消旋卡多曲,4~9个月10 mg/次1,0~24个月20 mg/次3,次/d,治疗组在对照组治疗基础上加用复方丁香罗勒口服混悬液,<6个月3 mL/次,6~12个月5 mL/次,1~2岁10 mL/次,3次/d,总疗程不超过7 d,观察治疗后排便次数、性状和临床症状的变化及不良反应。结果:治疗组患儿的止泻时间为(65.45±38.14)h,总病程为(94.73±36.43)h,对照组的止泻时间为(86.16±39.05)h,总病程为(118.77±47.89)h;治疗组显效率40.0%,有效率50.0%,总有效率90.0%,对照组显效率30.0%,有效率40.0%,总有效率70.0%,两组比较差异有统计学意义(P<0.05)。治疗组未发现明显不良反应。结论:复方丁香罗勒口服混悬液联合消旋卡多曲颗粒治疗婴幼儿轮状病毒性腹泻能较快减少腹泻次数,改善大便性状,有效缩短腹泻病程,用药后无明显不良反应发生。
Objective: To observe the clinical efficacy for the treatment of rotavirus diarrhea by using racecadotril granules combined with compound ocimum oil oral suspension.Methods: One hundred cases of acute diarrhea diagnosed as rotavirus infection were randomly divided into a treatment group of 50 patients and a control group of 50 patients.In the control group racecadotril was given based on conventional fluid therapy by age and weight,4~9 months 10 mg/time,10 to 24 months,20 mg/time,3 times a day,the treatment group in addition was given compound ocimum oil oral suspension,6 months 3 mL,6~12 months,5 mL,1~2 year-old 10 mL,3 times a day,with a total course of treatment of not more than 7 days.Patients were observed for defecation frequency,characteristics of clinical symptoms and adverse reactions after treatment.Results: Diarrhea time in the treatment group was(65.45±38.14) h,in the control group was(86.16±39.05) h,the total duration(94.73±36.43) h and(118.77±47.89) h,the times were shortened(P0.05).The total efficiency of the treatment group was 90.0%(40.0% for significant efficiency and 50.0% for efficiency),while of the control group was 70.0%(30.0% for significant efficiency and 40.0% for efficiency) and the difference was statistically significant(P0.05).No side effects were found in the treatment group.Conclusions: Using compound ocimum oil oral suspension combined with racecadotril granules to treat rotavirus diarrhea in infants and young children can quickly reduce the frequency of diarrhea and improve stool,effectively shorten the duration of diarrhea without adverse reactions after treatment.
出处
《儿科药学杂志》
CAS
2011年第2期28-30,共3页
Journal of Pediatric Pharmacy
关键词
消旋卡多曲颗粒
复方丁香罗勒口服混悬液
轮状病毒
腹泻
婴幼儿
Racecadotril granules
Compound ocimum oil oral suspension
Rotavirus
Diarrhea
Infants and young children