甲钴胺与泼尼松治疗腰椎间盘突出症临床疗效比较

Comparative Study on Methylcobalamin and Prednisone for the Treatment of Lumbar Disc Herniation

目的探讨甲钴胺与泼尼松治疗腰椎间盘突出症的临床疗效。方法腰椎间盘突出症患者随机分为观察组与对照组各164例,分别静滴甲钴胺与泼尼松,疗程6d,比较两组患者治疗前后VAS评分、Lasegue征角度及放射性疼痛、麻木症状改善率。结果 在治疗后2d、4d观察组VAS评分高于对照组(P<0.05),在治疗后13d观察组VAS评分低于对照组(P<0.01),治疗13d观察组Lasegue征角度明显高于对照组(P<0.01)。观察组与对照组治疗结束后放射性神经痛改善率分别为87.4%、86.9%(P>0.05),下肢麻木改善率分别为84.9%、76.8%(P<0.01)。结论甲钴胺可有效缓解腰椎间盘突出症的症状与体征。

Objective To observe the clinical effect of methylcobalamin and prednisone for the treatment of lumbar disc herniation （LDH）. Methods LDH were randomly divided into 2 groups,each of which included 154 cases.The observation group and control group were intravenous methylcobalamin and prednisone for 6 days, respectively.VAS score,Lasegue angle,improvement rate of radiological signs of pain and numbness symptom of patients were observed before and after treatment. Results VAS score of the observation group was higher than that of the control group （P〈0.05） at 2d,4d after the treatment,and was lower than that of the control group （P〈0.05） at 13d after the treatment.Lasegue angle of the observation group was significantly higher than that of the control at 13d after the treatment （P〈0.01）. The difference at other treatment time was not statistically significant.In the observation group and control group,the improvement rates of radioactive neuralgia after treatment were 87.4%,86.9%（P〉0.05）,respectively,and the improvement rates of lower extremity numbness were 84.9%,76.8%（P〈0.01 ）. Conclusion Methylcobalamin can relieve the symptoms and signs of LDH.