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抗肿瘤药罗米地辛的药理与临床研究 被引量：1

Pharmacology and clinical study of antineoplastic drug romidepsin
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摘要 抗肿瘤药罗米地辛是一种有效的组蛋白去乙酰化酶抑制剂,临床上用于治疗皮肤T细胞淋巴瘤。文中通过PUBMED对罗米地辛进行文献检索,并对其药理作用、药动学、临床研究、安全性及药物的相互作用等进行了综述。 Romidepsin is a potent histone deacetylase inhibitor,and is used in the treatment of cutaneous T-cell lymphoma（CTCL）.A literature search was conducted using PUBMED with the key word romidepsin.The pharmacological effects,pharmacokinetics,clinical research,safety and drug interactions of romidepsin were reviewed in this paper.
作者 杜燕京 封宇飞 傅得兴
机构地区 卫生部北京医院药学部
出处 《中国新药杂志》 CAS CSCD 北大核心 2011年第7期573-576,共4页 Chinese Journal of New Drugs
关键词 罗米地辛 组蛋白去乙酰化酶抑制剂 皮肤T细胞淋巴瘤 romidepsin histone deacetylase inhibitor cutaneous T-cell lymphoma
分类号 R979.1 [医药卫生—药品]
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参考文献13

  • 1CRISCIONE VD, WEINSTOCK MA. Incidence of cutaneous Tcell lymphoma in the United States, 1973 - 2002 [ J]. Arch Dermatol,2007,143 (7) :854 - 859.
  • 2FURUMAI R, MATSUYAMA A, KOBASHI N, et al. FK228 (depsipeptide) as a natural prodrug that inhibits class I histone dcacetylases [ J ]. Cancer Res,2002,62 ( 17 ) :4916 - 4921.
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  • 4GRANT C, RAHMAN F, PIEKARZ R, et al. Romidepsin: a new therapy for cutaneous T-cell lymphoma and a potential therapy for solid tumors [ J ]. Expert Rev Anticancer Ther, 2010, 10 (7) :997 - 1008.
  • 5SANDOR V, BAKKE S, ROBERT W,et al. Phase I trial of the histone deacetylase inhibitor, depsipeptide ( FR901228, NSC630176), in patients with refractory neoplasms [ J ]. Clin Cancer Res,2002,8 (3) :718 - 728.
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  • 8FOULADI M, FURMAN WL, CHIN T,et al. Phase I study of depsipeptide in pediatric patients with refractory solid tumors: a Children's Oncology Group report [ J ]. J Clin Oncol, 2006,24 (22) :3678 -3685.
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  • 10WHITTAKER S, DEMIERRE MF, KIM EJ,et al. Final results from a multicenter,international pivotal study of romidepsin in refractory cutaneous T-cell lymphoma[ J]. J Clin Oncol, 2010, 28 (29) :4485 -4491.

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中国新药杂志
2011年 第7期

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