丹酚酸B的药动学研究进展

Advances in studies of the pharmacokinetics of salvianolic acid B

丹酚酸B是目前研究较多的丹参酚酸成分之一,其口服吸收迅速,生物利用度低;分布取决于药物的理化性质、蛋白结合率及组织器官的特性;代谢具有非线性药动学特征,P450酶参与了此过程;排泄主要途径是胆汁。文中通过综述国内外有关丹酚酸B药动学研究进展,对丹酚酸B血浆生物样品预处理,检测方法,吸收、分布、代谢、排泄以及与其他药物相互作用几个方面进行了归纳分析。

Salvianolic acid B is one of the currently studied salvia miltiorrhiza phenolic acids.Its absorption is rapid,but the bioavailability is low.Its distribution depends on the physical and chemical properties,protein binding rate and characters of tissue and organs.Metabolism of salvianolic acid B shows a non-linear pharmacokinetic property,and P450 enzyme involves in the process.The major excretion organ for the component is via bile.In the article,we summarized the studies on the pharmacokinetics of salvianolic acid B,and focused on the following aspects： processing procedures of plasma sample,determination validation,absorption,distribution,metabolism,excretion and pharmacokinetic interaction with the other drugs.