慢性肝功能衰竭患者肝组织HIF-1α和SDF-1α表达的相关性分析

The hepatic expression of HIF-1α and SDF-1α in patients with chronic liver failure

目的观察缺氧诱导因子-lα(HIF-lα)和基质细胞衍生因子-lα(SDF-1α)在慢性肝功能衰竭患者肝组织中的表达状况。方法采用免疫组织化学法检测21例慢性肝功能衰竭患者及10名正常人肝组织HIF-1α和SDF-1α的表达。结果 21例患者肝组织HIF-lα和SDF-1α呈高表达,阳性率分别为57.1%和71.4%,明显高于正常肝组织(P<0.05);在患者肝组织中两者表达呈正相关(r=0.482,P<0.05)。结论慢性肝功能衰竭患者肝组织HIF-1α和SDF-1α表达增强,可能是HIF-1α上调了SDF-1α的表达,进而促进受损肝组织的自我修复。

Objective To investigate the hepatic expression of HIF-1α and SDF-1α in patients with chronic liver failure. Methods Liver tissues were obtained from 21 patients with chronic liver failure and 10 controls receiving liver resection for benign lesions,and HIF-1α and SDF-1α were stained immunohistochemically. Results HIF-1α and SDF-1α were overexpresscd in livers of patients with chronic liver failure. The positive rates were 57.1% and 71.4%,respectively,much higher than in the normal liver tissues （P〈0.05）;There was an positive correlation between the expression of HIF-1α and SDF-1α in chronic liver failure （r=0.482,P〈0.05）. Conclusion HIF-1α and SDF-1α are highly expressed in chronic liver failure, which might promotes the repainnent of injuried liver tissues.