囊虫病免疫诊断候选抗原研究进展

Advances in research on candidate antigens for immunodiagnosis of cysticercosis

猪囊尾蚴免疫诊断抗原的研究是囊虫病免疫诊断的基础。猪囊尾蚴抗原成分复杂,特别是虫体粗抗原,与多种寄生虫存在明显的交叉抗原成分,影响检测的特异性。近年来随着分子生物学的发展,重组抗原制备简单,检测效果良好,已成为囊虫病免疫诊断研究的热点。本文对近年来囊虫病免疫诊断抗原的分子生物学研究进展进行了综述。

Study of the antigens of Taenia solium is the basis for immunodiagnosis of cysticercosis.Taenia solium antigens have a number of components,which is particularly true of the parasite＇s crude antigens.Cross-reactivity with other helminth infections occurs with whole worm antigen and affects the specificity of the parasite＇s detection.Immunodiagnosis of cysticercosis has garnered attention because of recent advances in molecular biology,ready preparation of recombinant antigens,and the increased effectiveness of the disease＇s detection.This review describes recent advances in molecular biology research on antigens for use in immunodiagnosis of cysticercosis.