再生障碍性贫血患者血清甲状腺激素水平的临床研究

Clinical Study on Serum Thyroxin Level of Patients with Aplastic Anemia

采用放射免疫法检测143例再生障碍性贫血(AA)患者治疗前后甲状腺激素水平,并与正常人对照.结果AA患者治疗前及治疗后病情无好转时,其T_3、T_4明显低于对照组(P均<0.01),而促甲状腺素(TSH)无显著改变(P>0.05),当治疗后病情明显好转或基本缓解时,T_3、T_4值接近正常人(P>0.05),TSH也无明显改变(P>0.05).这种不伴TSH升高的低T_3、T_4考虑为甲状腺综合征中的低T_3、T_4综合征,与疾病分期有关,并与Karnofsky健康状况有关.

Radioimmunoassay (RIA) was used to determine the changes in serum thyroxin level of 143 patients with aplastic anemia (AA)before and after treatment. A comparative study was performed between the patients and normal subjects. The results showed that T3 and T4 levels of AA patients were lower than in control group (P<0. 01) when the disease didn't get better obviously after treatment and TSH didn't change (P>0. 05). T3 and T4 levels were approximately normal (P>0. 05)and TSH didn't change obviously (P> 0. 05) when the disease got better obviously or remission. The low T3 and T4 levels without TSH elevation can be considered as the low T3 and T4 syndrome in thyroid syndrome and are related to the disease staging and Karnofsky healthy status.