泌尿系感染患者中段尿液中肠球菌属的耐药性分析

Drug resistance of enterococcus in middle-segment urine of patients with in urinary tract infection

目的了解泌尿系感染患者中段尿液中肠球菌属的分布及其耐药情况。方法收集2019例泌尿系感染患者中段尿液进行细菌培养、鉴定及药敏试验。结果 454例中检出细菌493株,阳性率为22.49%,其中肠球菌属151株,分离率为30.63%,大肠埃希菌137株,分离率为27.79%;粪肠球菌对青霉素及呋喃妥因、喹诺酮类抗菌药物的耐药率明显低于屎肠球菌,屎肠球菌对喹奴普汀/达福普汀的耐药率明显低于粪肠球菌;粪肠球菌及屎肠球菌未见对万古霉素和替考拉宁耐药。结论肠球菌属在尿液中细菌检出率较高,对常见抗菌药物均存在不同程度的耐药性,对万古霉素和替考拉宁具有高度的敏感性,药敏试验结果可指导临床合理选用抗菌药物。

OBJECTIVE To analyze the resistance feature and the distribution of Enterococcus species isolated from middle-segment urine specimens.METHODS Totally 732 samples of middle-segment urine of patients infected in urinary tract were cultured,and the drug resistances were tested.RESULTS From them 493 strains in 454 cases were detected out,among which 151 strains were Enterococcus and 137 strains were Escherichia coli.The results of drug resistances showed the resistant rates of E.faecalis to penicillin and furadantin were lower than those of E.faecium,the resistant rate of E.faecium to quinupristin/dalfopristin was lower than that of E.faecalis.None of E.faecalis and E.faecium resisted to vancomycin and teicoplanin.CONCLUSION The detective rate of the Enterococcus is high in middle-segment urine specimens.The results reveal a different resistance to common antibiotics,but a high sensistivity to vancomycin and teicoplanin.The result of antibiotic susceptibility testing guides the rational use of antibacterial agents.