厄贝沙坦联用胺碘酮在心房颤动射频消融术后维持窦性心律的作用

Clinical effect of irbesartan combined with amiodarone on maintaining sinus rhythm in atrial fi- brillation patients after radiofrequency catheter ablation

目的观察厄贝沙坦联用胺碘酮在心房颤动（房颤）射频消融术后维持窦性心律的作用及其对左房大小的影响。方法52例房颤患者在三维标测系统指引下行射频消融术，术后随机分为两组：胺碘酮组（A组，25例）给予胺碘酮治疗，胺碘酮加厄贝沙垣组（B组，27例）给予胺碘酮加厄贝沙坦。观察两组治疗前后左心房大小及房颤复发情况。结果随访1年后，A组房颤发生率（28％）明显高于B组（22．2％），差异有统计学意义（P〈0．05）。B组左房内径较A组明显缩小（P〈0．05）。结论厄贝沙坦联用胺碘酮在房颤射频消融术后维持窦性心律较单用胺碘酮更有效，并可逆转左房扩大。

Objective To evaluate clinical effect of irbesartan combined with amiodarone on maintaining sinus rhythm in atrial fibrillation patients after radiofrequency catheter ablation. Methods Fifty - two cases of atrial fibrillation were divided into amiodarone group （ group A, 25 cases） and irbesartan combined with amiodarone group （group B, 27 cases） after radiofrequency catheter ablation. Results After Oneyear follow up,the 28% of patients in group A and 22.2% of patients in group B were suffer from atrial fibrillation （P 〈0. 05 ）. Compared with group B, the left atrial dimension of A goup was significant decreased （P 〈 0.05）. Conclusions Irbesartan combined with amiodarone is safe and effective on maintaining sinus rhythm in atrial fibrillation patients after radiofrequency catheter ablation.