婴儿肝炎综合征促肝细胞生长素治疗效果观察

Clinical observation on treatment of hepatocyte growth -promoting factor for infantile hepatitis syndrome

目的探讨促肝细胞生长素治疗肝炎综合征的疗效。方法收集2009年1月至2010年7月住院治疗的肝炎综合征患者80例，随机分成治疗组和对照组各40例，两组均采用抗病毒、能量合剂（肝泰乐、肌苷、门冬氨酸钾镁等）护肝利胆、菌栀黄退黄等治疗措施。治疗组在对照组治疗基础上加用促肝细胞生长素30μg（2m1），加入5％葡萄糖注射液100ml中静脉滴注，每天1次，连续治疗2周。结果治疗2周后，治疗组天门冬氨酸氨基转移酶（AST）和丙氨酸氨基转移酶（ALT）明显下降，而对照组ALT及AST虽然有所下降，但差异无统计学意义（P〉0．05）。对照组有效率95％，对照组有效率60％。结论促肝细胞生长素治疗婴儿肝炎综合征疗效显著，值得推广。

Objective To explore the clinical efficacy of hepatocyte growth - promoting factor in treatment of infantile hepatitis syndrome. Methods Eighty patients of infantile hepatitis syndrome were collected from January 2009 to July 2010, which were randomly divided into two groups. Forty cases as treatment group and 40 cases as control group were all treated by anti - virus, energy mixture （ glucurolactone, inosine, potassium magnesium aspartate,ete） , protecting liver and cholagogue and Yinzhihuang treatment. The treatment group from conventional therapy were treated with hepatoeyte growth - promoting factor injection （30 μg/2 ml）in 5% glucose injection（100 ml）, iv gtt, once a day for two weeks. Results After two weeks, the level of aspartate anainotransferase （AST） and alanine aminotransferase （ALT） in the treatment group was significant decline. Though the level of AST and ALT from control group was on the decline, there was no significant difference（ P 〉0. 05）. The effective rate was 95% in the treatment group and 60% in the control group. Conclusions The clinical efficacy of hepatocyte growth - promoting factor in treatment of infantile hepatitis syndrom is significant and the method is worth generalizing and applying.