替罗非班对不稳定型心绞痛患者疗效和近期心血管事件发生率的影响

Influence of tirofiban on effect and recent incidence of cardiovascular events in patients with unstable angina pectoris

目的评价替罗非班对不稳定型心绞痛（UAP）患者疗效和近期心血管事件发生率的影响。方法将78例UAP患者随机分为观察组40例和对照组38例，对照组采用常规抗凝治疗（阿司匹林十低分子肝素十氯吡格雷），观察组在对照组治疗的基础上加用替罗非班静脉持续点滴72h。治疗7d后观察心绞痛控制情况，治疗30d统计近期心血管事件发生率。结果治疗后7d观察组的总有效率显效率、显著高于对照组（χ2=4．9673，P〈0．05），治疗后30d观察组心血管事件的发生率显著低于对照组（χ2=3．9209，P〈0．01），两组30d内不良反应的发生率比较差异无统计学意义（P〉0．05）。结论在常规抗凝治疗的基础上加用替罗非班治疗不稳定型心绞痛能进一步获益，更加有效地控制心绞痛，减少不良心血管事件的发生，且不增加严重出血的发生。

Objective To evaluate the influence of tirofiban on effect and recent incidence of cardiovascular events in patients with unstable angina pectoris. Methods Seventy - eight patients with UAP were randomly divided into observation group （40 cases） and control group（38 cases） , the patients in control group took conventional anticoagulation therapy （ low molecular weight heparin ＋ aspirin ＋ clopidogrel） , the patients in the observation group were treated additionally with continuous intravenous tirofiban drip 72 h based on the control group. To observe angina pectoris control situation after 7 days, to statistical the recent incidence of cardiovascular events after 30 clays. Results After 7 days, the total efficiency of the observation group was significantly higher than that of the control group （ X2 ： 4. 9673, P 〈 0.05）. After 30 days, the cardiac events in the observation group were significantly lower than the control group （ X2 = 3. 9209, P 〈 0.01 ）. The incidence of cardiovascular reactions in the two groups was no significant difference within 30 days （ P 〉 0.05 ）. Conclusions It can further benefit from additional treatment with tirofiban in unstable angina on the basis of conventional antieoagulation therapy, and more effective control of angina, reduce the incidence of adverse cardiovascular events and does not increase the incidence of serious bleeding.