摘要
目的探讨DKK1与β-Catenin在食管鳞癌中的表达及与临床病理特征的关系。方法采用免疫组化二步法检测DKK1,β-Catenin在54例食管鳞癌中的表达情况,。结果 DKK1在食管鳞癌高中和低分化组中阳性率分别为82.14%和38.46%,在TNMⅠ、Ⅱ期和Ⅲ、Ⅳ期组中阳性率分别为43.47%和74.19%,肿瘤浸润深度分组(浅肌层,深肌层,外膜)中,DKK1阳性率分别为50.00%,42.86%,74.19%,在淋巴结转移组与非转移中DKK1阳性率分别为76.00%和48.28%,统计学显示,以上四个变量均有显著差异(P<0.05)。β-catenin在食管鳞癌高中和低分化组中阳性率分别为46.42%和88.46%,淋巴结转移组与非转移中阳性率分别为44.00%和86.21%,统计学显示两变量具有显著差异(P<0.05)。结论 DKK1,β-catenin在食管鱗癌分化、增殖,转移中起一定的作用,DKK1作为Wnt/β-Catenin经典信号传导通路的拮抗剂,有可能成为新的药物作用靶点。
Objective To determine the tissue expression of DKK1 and β-Catenin in Esophageal squamous cell carcinoma（ESCC）.and study the relationship with clinic pathologcal chractrastice.Methods The expression of DKK1 and β-Catenin in 54 ECSS tumors were examined by IHC.Results The rate of DKK1 expression in high-middle grade and low Grade ECSS tumor was 82.14% and 38.46%.respectively.As the same in TNM classification tumor differatiation preferation and lympl node metastasis Statistics show expression have a significantly positive correlation（P〈0.05）.Conclutions Our data imply that DKK1 andβ-Catenin is play the important role in Wnt/β-Catenin signal path and should be useful as a novel Wnt inhibitors in clinic therapy and probably as a therapeutic target for esophageal cancer.
出处
《医药论坛杂志》
2011年第2期20-22,25,共4页
Journal of Medical Forum
基金
河南省科技厅社会公益项目预研专项课题基金(341700700)
