静脉注射帕瑞昔布钠对食管癌术后患者静脉自控镇痛效果的影响

Effects of parecoxib sodium on patient-controlled intravenous analgesia sufentanil consumption after esophageal carcinoma surgery

目的观察静脉注射帕瑞昔布钠对食管癌术后病人静脉自控镇痛效果的影响。方法随机选取全麻下行食管癌根治术病人40例,麻醉诱导时分别给安慰剂或帕瑞昔布钠40㎎各20例,术后12h予相同剂量重复给药。观察术后24h和48h的PCIA舒芬太尼用量,同时记录病人的疼痛评分及不良反应。结果帕瑞昔布钠组术后PCIA舒芬太尼24h和48h用量显著低于安慰剂组,并且24h和48h的PCIA有效按压次数也低于安慰剂组(P<0.05),术后6、24和48h的疼痛强度视觉模拟(visual aualogne scale,VAS)评分显著低于安慰剂组(P<0.05),而不良反应的发生率两组间无显著性差异(P>0.05)。结论帕瑞昔布钠可使食管癌患者术后PCIA舒芬太尼用量减少,且镇痛效果优于对照组。

Objective To observe the impact of Parecoxib sodium on PCIA effect in esophageal cancer patients treated with radical esophagotomy. Methods Totally 40 patients were randomized to parecoxib or placebos group.The PCIA sufentanil consumption was recorded 24h and 48h post-operation and VAS scores were also recorded. Results The sufentanil consumption and the PCIA pressing times at 24h and 48h after operation in parecoxib group is significantly lower than placebo group（P〈0.05）.The VAS scores in two groups at 6h、24h and 48h are statistically significant different（P〈0.05）and adverse reaction reduced. Conclusions The application of Parecoxib sodium at induction and 12h after operation can reduce PCIA sufentanil consumption significantly after surgery.