摘要
目的探讨丙戊酸镁与碳酸锂治疗躁狂发作的疗效和不良反应的差异性。方法应用Meta分析对6篇丙戊酸镁与碳酸锂治疗躁狂发作对照研究的文献进行再分析,评价其合并效应量大小和综合显著性检验。结果丙戊酸镁自身对照比较的治疗效应极大,合并效应量d=-3.89,95%CI(-4.84,-2.94),Х^2=22.94,P〈0.01;治疗后丙戊酸镁与碳酸锂组间疗效比较差异无显著性,差异效应偏小,分别为Y合并=-0.06,95%CI(-0.22,0.10),Х^2=2.16,P〉0.05;丙戊酸镁不良反应发生率显著低于碳酸锂。结论丙戊酸镁治疗躁狂发作疗效显著,与碳酸锂相当,但丙戊酸镁安全性更高。
Objective To explore the difference in efficacy and adverse reactions between magnesium valproat and lithium carbonate in the treatmrent of manic episode. Methods Re-analyses were carried out on literatures of 6 control studies about magnesium valproat and lithium carbonate in the treatment of manic episode using Meta-analysis, merging effect size and comprehensive significance test were eveluated. Results Therapeutic effect of own control comparison of magnesium valproat was great, d=-3.89, 95%CI (-4.84,-2.94),Х^2 =22.94,P〈0.01;after treatment, there were no significant differences in group efficacy comparison, difference effects were smaller and respectively Ycmcrging=-0.06, 95%CI (-0.22, 0.10),Х^2=2.16, P〉0.05; the incidence of adverse reactions of magnesium valproat were significantly lower than that of lithium carbonate. Conclusion Magnesium valproat has a notable efficacy equivalent to lithium carbonate in the treatment of manic epi- sode, but the safety of the former is higher.
出处
《临床心身疾病杂志》
CAS
2011年第2期112-113,共2页
Journal of Clinical Psychosomatic Diseases
关键词
丙戊酸镁
碳酸锂
躁狂发作
临床疗效
不良反应
META分析
Magnesium valproat
lithium carbonate
manic episode
clinical efficacy
adverse reaction
Meta-analysis