抑郁症患者治疗前后神经心理学测验变化分析

Change analyses of neuropsychological tests of depression patients before and after treatment

目的通过研究抑郁症患者治疗前后神经心理学测验，评价其认知功能的变化。方法将45例抑郁症患者设为研究组，于人组当日及治疗8周后分别进行韦氏成人记忆量表中国版和中国修订韦氏成人智力量表测试；随机抽取本院职工、学生及志愿者30名设为对照组，于人组时进行两个量表的评定。结果研究组治疗后韦氏成人记忆量表、韦氏成人智力量表各因子评分均显著高于治疗前（P〈0.01）。研究组治疗前韦氏成人记忆量表、韦氏成人智力量表各因子评分均显著低于对照组（P〈0.05或0．01），治疗后长时记忆、短时记忆、瞬时记忆及记忆商数评分显著低于对照组（P〈0．05或0．01）。结论抑郁症患者发作期存在明显记忆、智能障碍，治疗后，随着临床症状的缓解其功能得到部分改善，但不能完全恢复到正常水平。

Objective To research the changes in cognitive function of depression through the neuropsychological test before and after treatment. Methods Forty-five depression patients were assigned to research group, tests carried out with the Weehsler Memory Scale （WMS-RC）, Wechsler Adult Intelligence Scale （WAIS-RC） on the same day of entering the group and after 8-week treatment; a total of 30 randomly selected employees, students and volunteers were assigned to control group and assessed with two sacles on entering the group. Results After treatment, each factor scores of both the WMS-RC and WAIS-RC were significantly higher compared with pretreatment in the research group （P〈0.01）. Each factor scores of both the WMS-RC and WAIS-RC before treatment （P〈0.05 or 0.01） and scores of long-term memory, short-term memory, instantaneous memory and memory quotient after treatment （P〈0.05 or 0.01） were significantly lower in the research than in the control group. Conclusion Depression patients have obvious memory impairment and disturbance of intelligence at the attack stage, after treatment these functions improve partially with the remission of clinical symptom, but doesn＇t completely recover to normal level.