摘要
目的：探讨增殖细胞核抗原（ＰＣＮＡ） 表达与甲状腺滤泡性肿瘤间的关系。方法：用免疫组织化学方法检测４４ 例甲状腺滤泡肿瘤中ＰＣＮＡ 的表达。结果：各组ＰＣＮＡ 阳性细胞平均百分率依次为：滤泡癌微小浸润型２２ ．９ ％ ±８ ．５５ ％ ；广泛浸润型２１ ．００ ％ ±４ ．７５ ％ ；滤泡腺瘤５ ．２４ ％ ±１ ．５８ ％ ，滤泡腺瘤与滤泡癌微小浸润型之间有显著性差异（ Ｐ＜ ０ ．０１） ，与广泛浸润型之间也有显著性差异（ Ｐ＜ ０ ．０１） 。结论：ＰＣＮＡ 对甲状腺滤泡性肿瘤的良恶性具有鉴别诊断价值。
Objective: To study the relationship between the expression of proliferative cell nuclear antigen (PCNA) and follicular tumors of thyroid. Methods: PCNA expression in 44 cases of thyroid follicular tumor were studied immunohistochemically. Results: The PCNA antigen-positive rate in minimally invasive follicular carcinomas (MIFC), widely invasive follicular carcinomas (WIFC ) and follicular adenomas (FA) were 22.90±8.55%, 21.00±4.75%and 5.24±1.58%respectively. There was a statistically significant difference between FA and MIFC or WIFC (P< 0.01). Conclusion: Determination of PCNA expression is valuable in distingushing benign tumors from malignant follicular thyroid tumor.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1999年第10期753-755,共3页
Chinese Journal of Clinical Oncology
基金
广西壮族自治区教委科研基金
