溴隐亭联合大剂量维生素B_6治疗高泌乳血症疗效观察

Effect of Bromocriptine combined with large doses of vitamin B_6 in treatment of hyperprolactinemia

目的:探讨溴隐亭联合大剂量维生素B6在高泌乳血症治疗中的作用。方法:门诊高泌乳血症患者163例,随机分为两组,观察组82例,服用溴隐亭和维生素B6,对照组81例,服用溴隐亭,于服药后的1、2、3、4、5、6个月测定血清PRL。结果:治疗前两组血清PRL水平无明显差异(P>0.05)。治疗6个月后,观察组血清PRL明显低于对照组(P<0.01)。观察组有75例血清PRL正常,占91.46%,68例停药,占82.92%;对照组有64例血清PRL正常,占79.01%,有41例停药,占50.61%。观察组中无恶心呕吐副作用出现,对照组中有8例出现恶心呕吐症状;治疗组1例因不能坚持服药,血清PRL出现反弹现象,对照组2例。停服溴隐亭1个月后观察组无复发,对照组有2例复发。结论:溴隐亭联合大剂量维生素B6治疗高泌乳血症可以缩短疗程,减少溴隐亭用量,降低药物副作用。

Objective： To explore the role of Bromocriptine combined with large doses of VitB6 in treatment of hyperprolactinemia.Methods： 163 cases with hyperprolactinemia were randomly divided into two groups,the observation group of 82 cases,took Bromocriptine and vitamin B6,the control group of 81 cases,took Bromocriptine,serum PRL after treatment 1,2,3,4,5,6 months.Results： Both groups had no significant difference in serum PRL before treatment（P〉0.05）,the serum PRL levels of observation group was significantly lower than that of the control group after treatment 6 months（P〈0.01）.Observation group,75 patients with serum PRL was normal,accounting for 91.46%,with 68 cases of withdrawal,82.92%;in the control group,64 cases of normal serum PRL,accounting for 79.01%,with 41 cases of withdrawal,accounting for 50.61%.Observation group had no side effects of nausea and vomiting,in control group,8 cases showed symptoms of nausea and vomiting;1 case of observed group,2 cases of control group,because they could not insist on taking the drug serum PRL rebound phenomenon.Stop taking Bromocriptine 6 months later,the observation group had no recurrence,recurrence in the control group with 2 cases.Conclusion： Bromocriptine combined with large doses of vitamin VitB6 in treatment of hyperprolactinemia can shorten the course of treatment,reduce the dosage of Bromocriptine,reduce side effects.