厄贝沙坦在改善老年高血压患者心肾功能中的临床应用价值

Clinical application of Irbesartan in improving heart and kidney function in elderly hypertensive patients

目的:探讨厄贝沙坦对老年高血压患者心肾功能的改善作用。方法:对收治的老年高血压患者采用厄贝沙坦(75 mg/d)治疗10～12个月,并探讨其在改善患者心肾功能中的作用。结果:56例老年高血压患者经过厄贝沙坦治疗后,其收缩压(126.7±7.9)和舒张压(81.2±6.5)mm Hg,均较治疗前明显降低(t=6.78,P=0.032);左室重量(191.2±40.1)g较治疗前明显减少(t=7.24、6.91;P=0.029、0.025),左室重量指数(112.3±21.3)g/m2较治疗前明显减小(t=6.91,P=0.029);肾动脉管壁厚度明显变薄,肾动脉内径明显增大(t=6.35、7.76;P=0.021,0.019);血β2-MG(2.5±0.6),尿β2-MG(0.15±0.02)水平均较治疗前明显降低(t=6.23、7.49;P=0.022,0.017)。结论:对于老年高血压病患者来说,厄贝沙坦既能降压,又能减轻或逆转心肾等器官损伤,值得临床推广使用。

Objective： To investigate the effects of Irbesartan in elderly hypertensive patients with heart and kidney function improvement.Methods： In this paper,the elderly patients with hypertension were treated with Irbesartan（75 mg/d） for 10-12 months,and to explore its function in improving the role of heart and kidney patients.Results： 56 cases with elderly hypertensive were treated with Irbesartan,the systolic and diastolic blood pressure were significantly lower than those before treatment（t=6.78,P=0.032）.LVM and LVMI were significantly reduced than those before treatment（t=7.24,6.91;P=0.029,0.025）.The renal artery wall was significantly thinner,and renal artery diameter was increased significantly（t=6.35,7.76;P=0.021,0.019） than before treatment.Blood and urine β2-MG level was significantly lower than before treatment（t=6.23,7.49;P=0.022,0.017）.Conclusion： For elderly patients with hypertension,Irbesartan can lower blood pressure,and reduce or reverse the damage the kidneys and other organs.So it is worthy of clinical use.