纳络酮治疗慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的53例临床观察，

Naloxone Treatment of Chronic Obstructive PuLmonary Disease with respiratory failure II Clinical Observation of 53 cases

目的：探讨纳洛酮治疗慢性阻塞性肺疾病（COPD）合并Ⅱ型呼吸衰竭的疗效。方法：将106例COPD合并II型呼吸衰竭患者随机分成两组，对照组给予常规治疗，治疗组在对照组治疗方法基础上加用纳洛酮治疗。结果：治疗组治疗前后在临床症状、体征、肺功能、血气分析等各项观察指标的改善上明显优于对照组，差异具有统计学意义（P＜0.05） ，两组未见明显不良反应。结论：纳洛酮治疗COPD合并Ⅱ型呼吸衰竭患者是一种安全有效的方法，值得临床推广应用。

Objective： To investigate the naloxone treatment of＂ chronic obstructive pulmonary disease （COPD） combined type II respiratory failure. Methods： 106 cases of type Ⅱ respiratory failure combined COPD patients were randomly divided into two groups, control group received conventional therapy, the treatment group therapy in the control group based on the use of naloxone treatment. Results： before and after treatment, clinical symptoms, signs, pulmonary function, blood gas analysis and other indicators of improvement observed is obviously better than the control group, the difference was statistically significant （P 〈0.05）, the two groups no significant adverse reaction. Conclusions： Naloxone treatment of COPD patients with respiratory failure combined Ⅱ is a safe and effective method, is worthy of clinical application.