非线性映射在矽肺病研究中的应用

Use of non linear mapping in diagnosis for silicosis

目的 将微量元素谱的非线性映射用于矽肺病研究。方法 以白银公司职工为研究对象。分析４２ 份Ⅰ、Ⅱ、Ⅲ期矽肺患者和４１ 份健康人发样中Ｃｒ 、Ｚｎ 、Ｍｇ 、Ａｌ、Ｃｄ 、Ｃｕ 、Ｓｅ 、Ｐｂ 、Ａｓ 、Ｍｎ １０ 种元素。取５０ 份为训练集、３３份为预测集。通过权重与相关分析缩减为６ 参数和５ 参数组， 用非线性映射作模式识别。结果 分类清晰的映射图。结论 微量元素谱的非线性映射技术在矽肺病研究中具有应用前景， 但微量元素的选择应考虑具体环境。

Objective To use the pattern of trace elements in non linear mapping in study on silicosis. Methods Ten kinds of trace elements,including chromium,zinc,magnesium,aluminum,cadmium,copper,selenium,lead,arsenic and manganese,were analyzed in 42 hair specimens from patients with of silicosis stages Ⅰ,Ⅱ and Ⅲ and 41 hair specimens from healthy controls.Fifty specimens were used as a training set and other 33 as a predictive set.Five parameter and six parameter groups were compacted with weighted and correlation analysis,and recognized with a non linear mapping model.Results A non linear mapping was obtained with clear classification. Conclusion Trace element pattern recognition in hair specimens with non linear mapping technique can be used in diagnosis for silicosis with promising prospect.But,it is important to choose adequate trace elements to be analyzed in the light of specific condition.