生长抑素联合巴曲酶治疗急性上消化道出血的临床观察

Clinical observation on acute upper gastrointestinal hemorrhage treated somatostatin combined with batroxobin

目的：探讨生长抑素联合巴曲酶治疗急性上消化道出血的临床疗效。方法：将80例急性上消化道出血患者随机分为观察组和对照组各40例，观察组采用生长抑素联合巴曲酶治疗，对照组采用垂体后叶素联合巴曲酶治疗，观察两组患者止血效果和不良反应。结果：观察组24h止血总有效率为85．00％，明显高于对照组的62．50％（P〈0．05）；止血时间为19．37±5．18h，短于对照组的27．884-6．54h（P〈0．05）；输血量为1．17±0．44U，少于对照组的2．61±0．53U（P〈0．05），48h再出血率为2．50％，低于对照组的10．00％（P〈0.05）。结论：生长抑素联合巴曲酶治疗急性上消化道出血疗效显著，止血速度快、输血量减少、早期再出血发生率低，值得临床推广应用。

Objective： To explore the clinical efficacy of acute upper gastrointestinal hemorrhage treated somatostatin combined with batroxobin. Methods： 80 cases patients with acute upper gastrointestinal hemorrhage were randomly divided into the imervention group（40 cases） and control group（40 cases）.The intervention group were treated somatostatin combined with batroxobin, the control group were treated pituitrin combined with batroxobin, their hemostatic effect were observed and compared. Results： The effective ratio of inter- vention group was significantly higher than that of control group （85.00% vs 62.50%, P〈0.05）; The haemostatic time of intervention was shorter than that of control group （19.37±5.18h vs 27.88 ±6.54h, P〈0.05）, the blood transfusion requirement and the rebleeding rate after the first 48 hours of intervention group （1.17±0.44U and 2.50%） was less than that of control group （2.61 ±0.53U and 10.00%）, there were significant differences （P 〈 0.05）. Conclusion： The？acute upper gastrointestinal hemorrhage treated somatostatin combined with batroxobin has significant effect, can lead to speeder up haemostatie pacing, fewer blood transfusion requirements and prevent early rebleeding effectively, and worthy of being recommended for use in clinical practice.