摘要
目的:探讨乌鳖颗粒对免疫功能的作用。方法:采用对单核巨噬细胞吞噬功能;对T淋巴细胞酯酶染色率;对溶血素抗体生成和DNCB诱导的迟发型变态反应等实验。结果:与空白组比较乌鳖颗粒大剂量组和中剂量组可明显增强吞噬指数(K)和吞噬系数(α);能迅速清除血液中异物,具有显著性差异(P<0.05,P<0.01)。乌鳖颗粒各剂量组可增加T淋巴细胞酯酶染色率,均能明显促进小鼠溶血素抗体生成,与空白组比较具有显著性差异(P<0.01),乌鳖颗粒大剂量和中剂量组对二硝基氯苯(DNCB)诱导小鼠迟发型超敏反应(DTH)具有明显的抑制作用,与模型组比较有显著性差异(P<0.01)。结论:乌鳖颗粒具有增强单核巨噬细胞吞噬功能的作用和增强T淋巴细胞酯酶染色率的作用。具有促进体液免疫和抑制细胞免疫的作用。
Objective：To study the effect ofWu Bie Granula on the immune function. Methods：The immunomodulatory effects of the Wubie Granula were measured by cleaning carbon particle method, Esterase staining rate of T lymphocytes,Hemolysin antibody formation and Delayed hypersensitivity of macrophage experiment. Results：Comparing to the control group,Wubie Granula could obviously promote the Phagocytic index and coefficient and quickly removed Foreign bodies in blood. Wubie Granula could increase the esterase staining rate of T lymphocytes and promote the Hemolysin antibody formation. It was significant difference compare with the control group（P〈0.01）. WuBie Granula could significantly Inhibited DTH compare with the control group（P〈0.01）. Conclusions：Wubie Granula could promote the. Phagocytosis function of Phagocyte as well as T lymphocyte transformation. Wubie Granula can promote both humoral and cellular immune suppression effect.
出处
《中国医药导刊》
2011年第2期297-298,共2页
Chinese Journal of Medicinal Guide
基金
江苏省康缘中医药科技创新资助课题(编号:HZ0804KY)
