胆汁性肝硬化的临床特征与病理学分析

Clinical Features and Pathological Analysis of Biliary Cirrhosis

目的:总结原发性胆汁性肝硬化(PBC)患者的临床特征与病理学表现,以深化对本病的认识。方法:分析我院收治45例PBC患者的临床表现、生化指标及肝组织病理特点。结果:PBC患者的临床症状多较为隐匿,其中以乏力、黄疸、皮肤瘙痒、纳差最为多见,在生化指标上,PBC患者出现多项肝功能的异常,均明显高于正常值,其中91.1%的患者出现AMA阳性,病理学表现各分期特点。结论:肝组织病理检查对PBC诊断有重要意义,PBC患者的肝脏病理改变以小胆管改变最明显,周围有炎性细胞浸润,汇管区细胞浸润现象明显,各期改变可相互混杂。

Objective：To summarize the clinical and pathological features of patients with primary biliary cirrhosis （PBC）,in order to deepen the understanding of the disease.Methods：The clinical and pathological features were analyzed from 45 cases of patients with PBC in our hospital.Results：The clinical symptoms of PBC patients were more hidden,among which the fatigue,jaundice,pruritus and anorexia were most common.Number of abnormal indicators of liver function in PBC patients,the indicators were significantly higher than normal, among which 91.1% patients showed the AMA-positiVe,the pathology showed the characteristics of the stages.Conclusion：The liver biopsy was important for diagnosis of PBC,the pathological changes of PBC patients was most obvious change in small bile duct,there was inflammatory cell infiltration in the small bile duct,the cell infiltration was most obvious in portal area,the change of each stages was mixed.