三种不同雾化吸入药物对气管切开患者痰液的影响

Effects of Three Different Atomization Inhalation Drugs on the Sputum of Tracheotomy Patients

目的:对三种不同雾化吸入药物对气管切开患者痰液的影响进行临床研究。方法:将所有入选120例病例,按照简单随机方法分为标准桃金娘油肠溶胶囊(吉诺通)组(A组)、传统组(B组)、半渗生理盐水组(C组)各40例。A组采用吉诺通(德国保时佳大药厂生产,批号:Z20060003)0.3g加入生理盐水250ml,使用时一次抽取30ml;B组采用传统雾化液30ml(生理盐水30ml加庆大霉素针剂8万u、a-糜蛋白酶5mg、地塞米松5mg),C组用0.45%生理盐水30ml。三组均用超声雾化器对气管切开患者进行雾化,每次15分钟,Q6h,7天为一疗程,一疗程后评价痰液粘稠度、痰痂形成及血氧饱和度。结果:痰液粘稠度Ⅰ度方面A组与B组疗效相当,但C组存在雾化过度(P<0.05);在痰液粘稠度Ⅱ度方面A组效果满意,优于C、B两组(P<0.05);在痰液粘稠Ⅲ度方面B组较A、C两组分泌物粘稠,存在雾化不足(P<0.05)。A组在一疗程结束后血氧饱和度优于B、C两组(P<0.05)。结论:标准挑金娘油对气管切开患者的雾化效果及血氧饱和度效果良好,综合效果优于传统方法及0.45%生理盐水方法。

Objective：To observe the effects of three different atomization inhalation drug on the sputum of traeheotomy patients. Methods： 120 tracheotomy patients were selected,and were divided randomly into three groups：Myr^ol enteric-coated capsule group（group A）,coventional group（group B） and semi-osmotic normal sodium group（group C）.Myrtol solution （Myrtol 0.3g addin normal sodium 250ml ）was adopted in Group A;eonventional atomized liquid was adopted in Group B,and semi-osmotic normal sodium atomized liquid was adopted in group C.AII patients of three groups recived atomization therapy using ultrasonic atomizer,15 minutes one time and every 6 hours,with a course of 7 days.Results：After treatment,there had a fairly effect about group A and group B on 1 degree spurn viscidity,but group B existed over-atomization（P〈0.05）;Group A had a more satisfactory effect than group B＆C on 2 degree spurn viscidity（P〈0.05）;Com pare to group A＆C, Group B existed atomization insufficiency（P〈0.05）.A^er one course treatment,the saturation of blood oxygen of group A had a significantly improvement than group B＆C（P〈0.05）.Conclusion：Myrtol solution atomization inhalation has a well effects on treating tracbeotomy patients than using conventional atomized liquid and semi-osmotic normal sodium.