糖化血红蛋白在糖尿病肾病检测中的意义

Saccharifies the Hemoglobin in Diabetes Nephrosis Examination Significance

目的:探讨糖化血红蛋白(HbAlc)的测定在糖尿病肾病的意义。方法:对156例糖尿病肾病患者的HbAlc、空腹血糖(FBG)、尿微量蛋白(mAlb)和a1-微球蛋白(α1-MG)的指标进行了检验分析。结果:糖尿病肾病患者血清HbAlc、尿mAlb显著高于健康组(P<0.01),糖尿病肾病患者HbAlc平均值越高,尿mAlb也越高,两者呈正相关。无DN组、早期DN组和临床DN组Glu的HbAlc和MAU差异均有高度显著意义(P<0.01),早期DN组和临床DN组与无DN组比较差异均有高度显著意义(P<0.01),临床DN组与早期DN组比较差异也有显著意义(P<0.05或P<0.01)。结论:糖化血红蛋白和尿mAlb可作为早期糖尿病肾病的诊断指标,对肾脏损害的程度和发展以及疗效观察有重要的临床意义。

Objective：To discuss the determination of saccharified hemoglobin （HbAlc） in diabetic nephrosis significance.Methods： To 156 example diabetic nephrosis patient＇s HbAlc, empty stomach blood sugar （FBG）,urine micro protein （mAlb） and al-microballoons protein （αl-MG） the target has carried on the examination analysis.Results：The diabetes nephrosis patient serum HbAlc and urine mAlb＇s showing is higher than a healthy set（P〈0.01）,the diabetic nephrosis patient HbAlc the average value is more high,mAlb also more high,both present positive correlation.Have no DN set,earlier period DN set and clinical DN set Glu HbAlc and MAU discrepancy all have highly shown significance （P〈0.01）.In early days DN set and clinical DN set with have no DN set compare the discrepancy all had highly showed significance （P〈0.01）.The clinical DN set and DN set compare discrepancy has already shown significance meaning as well in early days.（P〈0.05 or P〈0.01）.Conclusion：Saccharifies the hemoglobin and urinates mAlb to be possible to take the early diabetes nephrosis the diagnosis target,harms the degree and the development as well as the curative effect observation to the kidney has the vital clinical significance.