帕瑞昔布在直肠结肠癌手术的超前镇痛效果观察

Clinical Observation on Preemptive Analgesia Effects of Parecoxib for Patients with Colorectal Carcinoma Surgery

目的探讨帕瑞昔布在直肠结肠癌手术的超前镇痛效果。方法 42例全麻下直肠结肠癌手术患者随机分两组,每组21例。P组(帕瑞昔布组),手术开始前10分钟静脉注射帕瑞昔布40 mg(溶于生理盐水2 ml),C组(对照组)静脉注射生理盐水2 ml。手术结束使用PCIA镇痛(布托菲诺12 mg,溶于100 ml生理盐水)。分别记录2 h、6 h、12 h、24 h疼痛视觉评分(VAS)值,术后24 h内不良反应及PCIA自控按压次数。结果 P组在2 h、6 h、12 h VAS评分值明显小于C组,且24 h内自控按压次数小于C组(P<0.05)。24 h VAS评分值没有显著区别(P>0.05)。24 h内不良反应没有明显区别(P>0.05)。结论帕瑞昔布可以有效提高术后镇痛效果,具有安全有效性。

Objective To investigate the preemptive analgesia effect of parecoxib for patients with colorectal carcinoma surgery.Methods 42 patients undergoing colorectal carcinoma surgery under total intravenous anesthesia were randomly divided into two group： the parecoxib group（gorup P,n = 21） were intravenous injected parecoxib sodium at 10 minutes before operation and the control group（gorup C,n = 21） were intravenous injected 2 ml physiological saline.Patient controlled intravenous analgesia（PCIA） was used after operation in both groups.Visual analog scale（VAS） and adverse reaction at 2,6,12,24 hours were recorded after operation.Results VAS score in group P observed at 2,6,12 hours time point significantly less than that of in group C（P 0.05）.Adverse reaction of the medication was no significant difference in both group P and C（P 0.05）.Conclusion Intravenous parecoxib sodium before operation can safely,effectively offer preemptive analgesia for patients receiving colorectal cancer surgery.