相转移催化合成1-辛氧基-4-硝基苯醚

Synthesis of 1 Octyloxy 4 nitrobenzene Ether by Phase Transfer Catalysis

在氢氧化钾碱性介质中，以四丁基溴化铵Ｂｕ４ Ｎ＋ Ｂｒ－ （ＴＢＡＢ） 为相转移催化剂，由对硝基氯苯（ＰＣＮＢ） 和辛醇（Ｃ８ Ｈ１７ ＯＨ）反应合成了１辛氧基４硝基苯醚，研究了催化剂、碱、温度等因素对反应的影响，最佳工艺条件为：ｎ（ＰＣＮＢ）∶ｎ（Ｃ８ Ｈ１７ ＯＨ）∶ｎ（ＫＯＨ）∶ｎ（ＴＢＡＢ）＝ １∶１．２∶１．５∶０．０３，反应温度为１００℃，产品收率为８５ ．０ ％ ，经液相色谱分析，产品纯度为９５．５％ 。

Octyloxy 4 nitrobenzene ether was obtained using Bu 4N +Br -(TBAB) as phase transfer catalyst in the pre sence of KOH by reaction of 1 chloro 4 nitrobenzene (PCNB) and 1 octanol.Effects of catalyst,base and temperature were studied.The optimum molar ratio was determined:PCNB∶C 8H 17 OH∶KOH∶TBAB=1∶1.2∶1.5∶0.03.The reaction temperature was 100℃.The yield of the product was 85%,the purity of the product was over 95.5% by LC.