急性肺栓塞抗凝治疗40例临床观察

40 Cases Clinical Observation of Acute Pulmonary Embolism Anticoagulant Therapy

目的探讨急性肺栓塞的抗凝治疗临床疗效及安全性。方法将我院2009年11月到2010年12月收治的急性肺栓塞患者80例,随机分为溶栓组与抗凝组,每组40例。溶栓组给予尿激酶溶栓治疗;抗凝组给予肝素联合法华林进行抗凝治疗。治疗后比较两组的临床疗效,动脉血气指标（PaO2及PaCO2）变化,观察不良反应发生情况,并进行统计分析。结果抗凝组治疗后的PaO2及PaCO2明显优于溶栓组（P〈0.05）;抗凝组的显效率与总有效率均明显高于溶栓组（P〈0.05）;两组不良反应比较差异无统计学意义（P〉0.05）。结论 APE的抗凝治疗效果优于溶栓治疗,值得推广应用。

Objective acute pulmonary embolism of anticoagulation clinical efficacy and safety.Methods will be our hospital from 2009 November to December 2010 drug-induced acute pulmonary embolism 80 patients were randomly divided into thrombolysis group and anticoagulation group,40 cases in each group.Thrombolysis were given the urokinase fibrinolytic therapy,Anticoagulation were given heparin joint law shenyang antithrombotic therapies.After treatment compared with two groups of clinical curative effect,arterial blood gas index（PaO2 and PaCO2） change,observe adverse reaction,and statistical analysis.Results anticoagulant treatment group PaO2 and after PaCO2 obviously superior to thrombolysis group（P 0.05）.Anticoagulation group of significant efficiency and the total effective rate were significantly higher in thrombolysis group（P0.05）.Two groups of adverse reaction compare difference was statistically significant（P 0.05）.Conclusion APE in the anticoagulant therapy effect is better than that of fibrinolytic therapy,it is worth popularizing.