环磷酰胺、米托蒽醌及顺铂联合治疗晚期乳腺癌的临床疗效

The Clinical Efficacy of Conbination Chemotherapy of Cyclophosphamide Mitoxantrone and Cisplatin in the Theatment of Advanced Breast Cancer

目的 评价环磷酰胺、米托蒽醌及顺铂（ＣＭＰ方案）联合治疗晚期乳腺癌３９例的疗效。方法环磷酰胺６００ｍｇ／ｍ２，静冲，ｄ１；米托蒽醌１０ｍｇ／ｍ２；静滴，ｄ１；顺铂３０ｍｇ／ｍ２，静滴，ｄ１、２、３。 ２１天为１周期。结果总有效率５９％（２３／３９），完全缓解率１０．３％（４／３９），中位缓解期６．８月，中位生存期１３．４月。对软组织转移的有效率６７．９％（１９／２８），肺、胸膜、骨、肝转移有效率分别为５／１０、３／６、２／６、１／４。初治有效率６３．６％（２１／３３），复治者２／６。本组病人有不同程度胃肠道反应、脱发及骨髓抑制；未发现肾毒性及心脏毒性。结论ＣＭＰ方案是治疗晚期乳腺癌的有效方案。

Objective To evaluate the clinical results of conbination chemotherapy of cyclophosphamide, mitoxantrone and cisplatin(CMP regimen)in the beatment of 39 cases of advanced breast cancer. Method Cyclophosphamide was given op mg/m2 intravenous injection(IV) on day 1, Mitoxantrone 10 mg/m2IV drops on day 1. Cisplatin 30 mg/m2IV drops on days 1,2,3 .The treament was recycled every 21 days. Results The overall objective response rate was 59% (23/59)with a CR rate of 10.3%(4/39) .The median remittent duration was 6. 8 months and the madian survial bine was 13.4 months . The effective rate of soft tissue metastasis was 67 .9% (19/28). Lung metastasis responded in 5/10, pleura metastasis in 3/ 6,bone metastasis in 2/6, live metastasis in 1/4. The effective rate of previously untreated patients was 63. 6% (21/33). Among 39 cases, emesis. Leukopenia and thrombocytopenia was detected respectively in 41 %,76. 9%,33. 3%. The gastro- intestinal reaction or trichomadesis was seen in 94. 9%, 84. 6% respectively. No cardionephric toxity was observed. Conclusions CMP regimen is regarded as a better regimen for advanced breast cancer.