HE4在卵巢癌患者血清中的表达及其临床意义

The Expression of Serum HE4 in Patients with Varian Carcinoma and its Significance

目的研究卵巢癌患者血清中HE4水平，为卵巢癌的临床诊断和鉴别诊断提供参考。方法用ELISA检测121例妇女血清中HE4水平。其中78例盆腔肿瘤患者按术后病理结果分为卵巢癌组（n=27）和良性病变组（n=51）；43例体检健康妇女作为正常对照组（n=43）。综合评价HE4检测的临床价值。结果卵巢癌组HEA水平为581．5±445．7；良性病变组HE4水平为51．4±22．9；正常对照组HEA水平为36．7±12．0。HE4诊断卵巢癌的敏感性和特异性分别为66．7％和98．0％。结论血清HE4水平检测是诊断卵巢癌的良好指标。

Objective To investigate the expressions of serum HFA in the patients with ovarian carcinoma, and to serve as guides for diagnosis and differential diagnosis. Methods The levels of serum HFA in women were detected by ELISA. The patients were divided into two groups according to their postoperative pathology ： the ovarian carcinoma group （n = 27 ） and the benign group（ n = 51 ） ; 43 healthy women were looked as nomm] control group （n = 43）. We evaluated the clinical value based on the detection of HE4. Result The level of serum HE4 in ovarian carcinoma group were 581.5 ± 445.7; The level of serum HE4 in the benign groups were 51.4 ± 22.9;the level of serum HFA in the normal control group were 36.7 ± 12.0. The sensitivity and the specificity of HE4 were 66.7% and 98.0% . Conclusions HE4 is a helpful biomarker for ovarian carcinoma diagnosis.