C-反应蛋白与肿瘤坏死因子-a检测指标对冠心病临床意义探讨

Clinical significance discuss on C - reactive protein and tumor necrosis factor detection for coronary heart disease

目的探讨C-反应蛋白（cRP）和肿瘤坏死因子-a（TNF—a）与冠心病严重程度关系。方法选择30例心绞痛患者，20例心肌梗死患者，30例健康者，分别检测CRP和TNF—a水平。结果心绞痛组和急性心肌梗死组和TNF—a水平均高于非冠心痛患者组，差异极显著（P〈0．01），急性心肌梗死组cRP水平显著高于心绞痛组（P〈0．01），急性心肌梗死组TNF—a水平明显高于心绞痛组（P〈0．05）。结论血清CRP和TNF—a水平作为冠心病患者病情检测指标，其升高程度与冠状动脉粥样硬化程度有明显相关性。

Objective To investigate relationship between the levels of C - reactive protein （CRP） and tumor necrosis factor- a （TNF- a） of coronary heart disease. Methods 30 cases of angina pectoris, 20 patients with myocardial infarction, 30 healthy individuals were selected to detect levels of CRP and TNF - a. Results Angina poctoris and acute myocardial infarction group and TNF - a were higher than non - CHD patients, the difference was significant （P 〈 0.01）, acute myocardial infarction line CRP levels were significantly higher than the SA group （P 〈 0.01 ）, acute myocardial infarction, TNF- a levels were significantly higher than that of angina pectoris group （P 〈 0.05）. Conclusions Serum levels of CRP and TNF - a in patients with coronary heart disease as the detection index, the higher the degree of coronary atherosclerosis correlated significantly.