吸毒人群丙型和乙型肝炎病毒感染的血清流行病学研究

A sero epidemiological study of HCV and HBV infection among intravenous drug abusers

目的 调查广州市吸毒人群丙型肝炎病毒（ＨＣＶ） 和乙型肝炎病毒（ＨＢＶ） 的感染状况。方法 在广州市两所戒毒所４８３ 名男性吸毒人员中，用酶标记免疫（ＥＬＩＳＡ） 法，调查ＨＢＶ、ＨＣＶ感染情况，并以正常人群作对照组观察。结果 广州市吸毒人群中，ＨＣＶ、ＨＢＶ的感染率及这两种病毒的混合感染率，分别为６７－４９％ 、９０－４８ ％ 、６２－７３％ ，明显高于正常人群对照组的３－７５％ 、５５－６３ ％ 、３－７５％ 。结论 静脉吸毒是ＨＢＶ、ＨＣＶ感染的主要危险因素。广州市吸毒人群当中。

Objective To investigate hepatitis B and C virus infection in drug addicts in Guangzhou.Methods Serum samples from drug users and normal control people were collected. Serum antibodies against hepatitis C virus (HCV) and hepatitis B virus (HBV) were detected by ELISA. Results The results showed that hepatitis prevalence is significantly higher among the drug users than that in normal control group (for HCV 67.49% to 3.75%, for HBV 90.48% to 55.63%, and for the mixed infections 62.73% to 3.75%). Conclusion In Guangzhou, the very high infection rates of HBV and HCV were found in drug addicts. Our results emphasize intravenous drug use is the major risk factor for HBV and HCV infections.