移植肝的急性排斥反应

Acute rejection in hepatic allograft.

目的 分析供、受者年龄， 受者性别， 术前原发疾病， 肝、肾功能以及免疫抑制剂的使用对移植肝的急性排斥反应产生的影响。方法 对玛丽医院从１９９１ 年１０ 月至１９９８ 年９ 月发生移植肝急性排斥反应的所有病例进行回顾性分析。结果 ８１ 例患者做了８３ 例次肝移植， 共发生急性排斥反应７０ 例次， 发生率为５３％ 。经过统计学分析， 发现使用普乐可复（ＦＫ５０６） 的受者， 急性排斥反应的发生率较使用环孢素Ａ和硫唑嘌呤组为低。供、受者的年龄， 受者性别， 术前原发疾病以及肝、肾功能对急性排斥的发生没有明显的影响。结论 ＦＫ５０６ 不仅能够明显降低急性排斥反应的发生率， 而且能够有效治疗该并发症。

Objective To investigate whether the incidence of acute rejection was influenced by the age of donors and recipients, recipients'sex, primary diseases, pre operative liver biochemistry and renal function, and the use of immunosuppressive drugs.Methods Eighty three transplants at Queen Mary Hospital from October 1991 to September 1998 were analyzed retrospectively.Results The age of the donors and recipients, recipients'sex, primary diseases, and pre operative liver biochemistry and renal function did not significantly influence the incidence of acute rejection ( P > 0.05 ). The incidence of rejection in the group of patients who received FK506 treatment was lower than that in cyclosporine A and azathioprine treated group.Conclusion The use of immunosuppressive drugs may influence the episode of acute rejection. Incidence of acute rejection can be decreased by using FK506.