圣约翰草提取物治疗女性更年期抑郁症对照研究

A comparative study about efficiency of StJohn's wort extract in the treatment of female patients with involutional depression

目的评价圣约翰草提取物治疗女性更年期抑郁症患者的疗效及安全性。方法 64例更年期抑郁症患者随机分为研究组32例及对照组32例,分别服用圣约翰草提取物和帕罗西汀,疗程均为6周。基线时及治疗后第2、4、6周末采用临床总体评定量表(CGI),汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、不良反应量表(TESS)评价疗效和安全性。结果研究组有效率为81.25%,对照组有效率为84.38%,两组之间差异无统计学意义(P>0.05)。两组HAMD评分值与HAMA评分值从第2周末开始,较基线值比较差异均有统计学意义(P<0.01)。两组之间比较,差异无统计学意义(P>0.05)。两组不良反应较轻,但治疗后第6周末,研究组TESS评分值低于对照组,其差异有统计学意义(P<0.05)。结论圣约翰草提取物治疗更年期抑郁症有较好疗效,不良反应轻,安全性高。

Objective To investigate the efficiency and safety of St. John＇s wort extract in the treatment of female patients with involutional depression. Methods A total of 64 female patients with involutional depression were randomly divided into study group treated with St. John＇s wort extract and control group treated with paroxetine for 6 weeks. Efficiency and safety were assessed with Clinical Global Impressions （CGI） , the 24 -item Hamilton Depression Rating Scale （HAMD -24 ）, Hamilton Anxiety Rating Scale （HAMA）, Treatment Emergent Symptom Scale （TESS） at the baseline, the 2nd weekend, 4th weekend and 6th weekend after treatment. Results There was no significant difference in the effective rate between study group and control group （ 81.25% vs. 84.38% , P 〉 0.05 ）. Compared with the baseline, total scores of HAMD and HAMA in the two groups decreased significantly from the 2nd weekend （ P 〈0.01 ）. There were no significant differences in total scores of HAMD and HAMA between the two groups at each interview - point （ P 〉 0.05 ）. Side effects were few in both of the groups, but the score of TESS in study group was significantly lower than that in control group （ P 〈 0.05 ）. Conclusion St. John wort extract is effective for the treatment of involutional depressive with less side effects and high safety.