磷酸肌酸钠治疗黄疸早产儿心肌损伤的临床研究

A clinical study on myocardial injury of premature infants with jaundice treated with sodium phosphocreatine

目的:评估磷酸肌酸钠(PC)治疗黄疸早产儿心肌损伤的临床效果。方法:观察2006年1月～2009年12月石家庄第一医院儿科收治的139例黄疸早产儿心肌酶变化和临床特点,有CK或CK-MB之一异常的89例随机分为对照组42例和PC组47例,PC组在对照组常规治疗的基础上加用磷酸肌酸钠1g/d,连用7天。比较治疗前后CK、CK-MB变化的幅度。结果:黄疸早产儿心肌损伤PC治疗后,CK、CK-MB的变化显著,差异有统计学意义(P<0.05),尤其是黄疸合并症者,变化非常显著(P<0.01)。但单纯黄疸者PC治疗后,CK的变化显著,CK-MB的变化无统计学意义(P>0.05)。48例心电图检查有异常,部分有一过性临床指标异常。全部心脏彩超无一异常。结论:磷酸肌酸钠治疗黄疸早产儿心肌损伤临床效果显著,安全有效。

Objective：To evaluate the therapeutic effect of sodium phosphocreatine on myocardial injury of premature infants with jaundice.Methods：The changes of myocardial enzymes and clinical characteristics of 139 premature infants with jaundice in the hospital from January 2006 to December 2009 were observed,89 premature infants with abnormal CK or CK-MB were divided into control group（42 premature infants） and treatment group（47 premature infants）,the premature infants in treatment group were treated with sodium phosphocreatine on the basis of conventional treatment in control group,1 gram a day for 7 days.The changes of CK and CK-MB before and after treatment were compared.Results：After treating myocardial injury with sodium phosphocreatine,the changes of CK and CK-MB in premature infants with jaundice were significant（P〈0.05）,especially for the premature infants with jaundice complications（P〈0.01）.For the premature infants with simple jaundice,the change of CK is significant,but there was no significant difference in the change of CK-MB（P〉0.05）.48 premature infants were found with abnormal electrocardiogram results,and partial premature infants had transient abnormality of clinical indexes;no abnormality of cardiac ultrasound was found.Conclusion：The therapeutic effect of sodium phosphocreatine on myocardial injury of premature infants with jaundice is good,the method is safe and effective.