HPD对实验性急性肝损伤的保护作用

Effect of HPD on protection of experimental acute hepatic injury

对ＨＰＤ的保肝作用进行了药效学的研究。实验中采用了ＨＰＤ两个剂量（８０ｍｇ／ｋｇ，４０ｍｇ／ｋｇ），研究了这两个剂量对于ＣＣｌ４ 和醋氨酚所致的小鼠急性肝损伤的保护作用。实验结果表明，ＨＰＤ８０ｍｇ／ｋｇ 可使给ＣＣｌ４ 和醋氨酚后的小鼠血清中谷丙转氨酶、乳酸脱氢酶的活性显著降低（分别与ＣＣｌ４ 损伤组和醋氨酚损伤组比较） ，病理切片表明能明显减轻上述两种化学物质所致的肝脏病理损害。

To evaluate the hepatoprotective effect of HPD,the models of acute hepatic damage induced by carbon tetrachloride (CCl 4) and acetaminophen in mice were employed. The results showed that 10% CCl 4 0.1ml·10g -1 could increase the ALT in mice while HPD could greatly decreased the alanine transaminase activity and GOT. HPD (80mg/kg) twice a day could significantly improve the histopathologic injuries in these models owing to the inhibition of lipid peroxidation by HPD.