硫酸镁对妊高征孕鼠重要器官的影响

EFFECT OF MAGNESIUM SULFATE ON MATERNAL ORGANS IN PTH RATS

目的 探讨硫酸镁对妊高征孕鼠主要器官的影响。方法 选择Ⅱ级Ｗｉｓｔａｒ 大鼠，随机分为３ 组。自妊娠第１４ 天，对照组孕鼠皮下注射生理盐水，模型组孕鼠皮下注射亚硝基左旋精氨酸甲酯（Ｌ－ ＮＡＭＥ） ，治疗组孕鼠皮下注射Ｌ－ ＮＡＭＥ ，并自妊娠第１６ 天肌肉注射硫酸镁，直到分娩。测定孕鼠尾动脉收缩压、尿蛋白、血小板数、红细胞压积和肝肾功能；观察肝、肾、脑等器官病理组织学变化。结果 与模型组比较，治疗组孕鼠血压降低、尿蛋白减少，红细胞压积降低、血小板数增加、血清ＣＲＥ 及ＵＡ降低，肾、脑组织损伤明显改善，但血清ＡＬＴ及肝组织损伤无明显变化。结论 硫酸镁可明显改善妊高征孕鼠重要器官（ 尤其肾、脑） 的病理生理及病理组织学变化，从而缓解妊高征特征。

Objective: To investigate the effect of magnesium sulfate on the main organs in pregnancy-induced hypertension rets. Methods Wistar rats were divided into three groups randomly. Beginning from the 14th day of gestation, saline solution was given subcutaneously in control group, L-NAME was given subcutaneously in model group and treatment group, in addition, magnesium sulfate was given intramuscularly form the 16th day of gestation in treatment group. Blood pressure, urine protein, platelet count, hematocrit function of kindney and liver were determined. Renal, hepatic and cerebral histology were studied.Results: Comparied with model group. blood pressure, urine protein, hematocrit, serum CRE and UA were decreased while platelet count were increased significantly, but serum ALT was not changed significantly in treatment group. Moreover, renal and cerebral injuries were improved significantly, but hepatic injury was not improved significantly in treatment group. Conclusion: Magnesium sulfate may relieve pathohistological and pathophysiological changes of maternal organs in PIH rats, therefore improve symptoms of PIH