NO与前列腺增生梗阻性逼尿肌不稳定的关系

The relationship between nitric oxide and detrusor instability secondary to benign prostatic hyperplasia obstruction

目的 探讨一氧化氮（ ＮＯ） 与前列腺增生（ＢＰ Ｈ） 梗阻性逼尿肌不稳定的关系。方法 采用比色法测定８ 例无排尿异常的正常对照组和１０ 例前列腺增生梗阻不稳定组、６ 例梗阻稳定组的膀胱逼尿肌ＮＯ 含量。结果 正常对照组、梗阻稳定组、梗阻不稳定组逼尿肌组织中ＮＯ 含量分别为１８ ．２ ±１ ．７ 、１７ ．１ ±１ ．２ 、９ ．２ ±１ ．８μｍｏｌ／Ｌ。梗阻不稳定组较正常对照组和梗阻稳定组ＮＯ 含量明显降低（ Ｐ＜ ０ ．０１） ，正常对照组和梗阻稳定组之间无明显差别（ Ｐ＞ ０ ．０５） 。结论 ＮＯ 可能参与ＢＰＨ梗阻性逼尿肌不稳定的产生，提示应用ＮＯ 供体膀胱内灌注治疗不稳定膀胱的可能。

Objective\ To study the relationship between nitric oxide(NO)and detrusor instability secondary to benign prostatic hyperplasia(BPH) obstruction.Methods\ Patients were devided into three groups:10cases of BPH with detrusor instability(DI),6 cases of BPH with detrusor stability (DS),8 cases of control.The level of NO in detrusor muscular specimens was determined with the colormetric methods.Results\ The level of NO in BPH with DI group,BPH with DS group and control group were 9.2±1.8,17.1±1.2 and 18.2±1.7μmol/L respectively.The level of NO in BPH with DI group was significantly lower than in BPH with DS group and in control group(P<0.01).There were no significant difference between BPH with DS group and control group (P>0.05).Conclusion\ It is suggested that NO to play some role in the pathogenesis of detrusor instability secondary to BPH obstruction,and these finding might lead to a treatment for bladder instability by the use of intravesical instillation of NO donors.