期刊文献+

p53与肝癌的基因治疗 被引量:1

下载PDF
导出
摘要 肝癌是我国乃至全世界最常见的癌症之一,我国的肝癌发病率和死亡率占全球每年新发病率和死亡人数的55%[1],其中80%以上的肝癌是肝细胞性肝癌。抑癌基因的突变、缺失及失活在肝癌的发生发展中起着关键性的作用。目前,新发现的抑癌基因层出不穷,较常见的有p53、p16、Rb、BCL-XS等。
出处 《九江学院学报(自然科学版)》 CAS 2011年第1期67-69,共3页 Journal of Jiujiang University:Natural Science Edition
  • 相关文献

参考文献14

  • 1Parkin M, Bray F, Ferlay J, et al. Global cancer statistics 2002 [ J ]. CA Cancer J Clin, 2005, 55 (2): 74.
  • 2Staib F, Hussain SP, Hofseth LJ, et al. TP53 and liver carcinogenesis [ J ]. Hum Mutat, 2003, 21 (3): 201.
  • 3Lipinsiki KS, Jieha AH, Krausz E, et al. Tumour-specific therapeutic adenoviro s vectors: repression of transgene expenssion in healthy cells by endogenous p53[J]. Gene Ther, 2001, 8 (4): 274.
  • 4Reiser M, Neumann I, Schmiegel W, et al. Induction of cell proliferation arrest and apoptosis in hepatoma cells through adenoviral - mediated transfer of p53 gene [J]. J Hepatol. 2000, 32 (5) : 771.
  • 5施明,王福生,刘明旭,张冰,雷周云,邱兆华,高兰兴,吴祖泽.重组腺病毒载体介导的人野生型p53基因增强肝癌细胞对化疗药物的敏感性[J].中国肿瘤生物治疗杂志,2001,8(2):80-83. 被引量:4
  • 6施明,王福生,刘明旭,金磊,雷周云,邱兆华,高兰兴,吴祖泽.重组腺病毒介导的人野生型p53、GM-CSF和B7-1基因在肝癌细胞中的表达[J].肿瘤防治研究,2002,29(2):123-125. 被引量:4
  • 7Habib NA, Hodgson H J, Emoine N, et al. A phase Ⅰ/Ⅱ study of hepatic artery infusion with wtp 53 CMV -Ad in metastatic malignant liver tumours [J]. Hum Gene Thel, 1999, 10: 2019.
  • 8朱志兵 刘积良 隋捷.重组人p53腺病毒治疗晚期难治性肝癌的临床研究[J].中华医药杂志,2004,3(11):11-14.
  • 9Terence K WL, Jtm - Song H, Sheung F, et al. Gene delivery using a receptor - mediated gene transfar system targeted to hepatocellular earcinomcells [J]. Int J Cancer, 2001, 93: 393.
  • 10郭英,曾益新,王坤,朱孝峰,罗慧玲,郑美莲,李满枝,陈积圣.腺病毒介导的p53抑制肝癌生长的实验研究[J].中华肝脏病杂志,2001,9(S1):43-45. 被引量:6

二级参考文献46

  • 1牛焕章,滕皋军,邓钢,陈晟,何仕诚,汪盛齐,卢勤,李国昭,陈龙桂.兔VX2肝癌模型的影像学表现和栓塞技术的实验研究[J].中国医学影像技术,2006,22(6):797-800. 被引量:17
  • 2SambrookJ RussellDW.分子克隆实验指南,第3版[M].北京:科学出版社,2002..
  • 3Leong ASY.Epidemiology,risk factors,etiology,premalignant lesions and carcinogenesis[M].//Leong ASY,Liew CT,Lau JWY,et al,Hepatocellular carcinoma:contemporary diagnosis,investigation and management.London:Arnold,1999,1-17.
  • 4Pauser S,Wanger S,Lippmann M,et al.Evaluation of efficient chemoembolization mixtures by magnetic resonance imaging therapy monitoring:An experimental study on the VX2 tumor in the rabbit liver[J].Cancer Res,1996,56:1863-1867
  • 5Habib NA,Hodgson HJ,Lemoine N,et al.A phase Ⅰ/Ⅱ study of hepatic artery infusion with wtp53-CMV-Ad in metastatic malignant liver tumours[J].Hum Gene Ther,1999,10:2019 -2034.
  • 6Bookstein R,Demers W,Gregory R,et al.P53 gene therapy in vivo of hepatocellular and liver metastatic colorectal cancer[J].Sem in oncol,1996,23:66-77.
  • 7Hirao K,Sugita T,Kubo T,et al.Targeted gene delivery to human osteosarcoma cells with magnetic cationic liposomes under a magnetic field[J].Int J Oncol,2003,22:1065-1071.
  • 8Gautam A,Waldrep JC,Densmore CL,et al.Growth inhibition of established B 16-F 10 lung metastases by sequential aerosol delivery of p53 gene and 9-nitrocanptothecin[J].Gene Ther,2002,9:353-357
  • 9Riva CM.Restoration of wild-type p53 activity enhances the sensitivity of pleural metastasis to cisplatin through an apoptotic mechanism[J].Anticancer Res,2000,20:4463-4471.
  • 10Pastorino F,Brignole C,Marimpietri D,et al.Targeted delivery of oncogene-selective antisense oligonucleotides in neuroectodermal tumors:therapeutic implications[J].Ann N Y Acad Sci,2004,1028:90-103.

共引文献25

同被引文献6

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部