膝骨性关节炎滑膜神经纤维分布和神经突起因子表达及意义

Study on expression and significance of Neuritin and distribution of nerve fibers in synovium of osteoarthritis.

目的探讨神经纤维和神经突起因子(Neuritin)在膝骨性关节炎中的表达和意义。方法应用免疫组化的方法检测Neuritin在膝骨性关节炎和单纯膝关节外伤膝关节滑膜中的表达;用Gless神经纤维染色法观察膝骨性关节炎和单纯膝关节外伤膝关节滑膜中神经纤维分布。结果 30例膝骨性关节炎滑膜中阳性表达Neuritin 22例(73.3%),30例对照滑膜中阳性表达Neuritin 13例(43.3%);神经纤维在膝骨性关节炎滑膜的分布较单纯膝关节外伤广泛。结论 Neuritin和神经纤维可能参与膝骨性关节炎膝关节疼痛的发生。

Objective To study the significance of nerve fibers and Neuritin in pathogenesis of pain in osteoarthritis（OA）.Methods The detection of Neuritin expression in synovial tissues in OA and simple knee arthrotrauma was examined with immunohistochemical analysis technique and the examination of distribution of nerve fibers in synovial tissues in OA and simple knee arthrotrauma adopted Gless nerve fibers staining.Results The positive expressions of Neuritin in synovial membranes of 30 cases of OA and 30 controls were 22/30（73.3%） and 13/30（43.3%） respectively.The distribution of nerve fibers was more extensive in synovial tissues in OA than simple knee arthrotrauma.Conclusion Neuritin and nerve fibers may probably play an important role in the pathogenesis of pain in cases of OA.