辛伐他汀预处理对脾切除大鼠术后认知功能的影响

Influence of Pretreatment with Simvastatin on Postoperative Cognitive Function in Splenectomized Rats.

目的通过Y-型迷宫实验来探讨辛伐他汀预处理对脾切除大鼠认知功能的影响。方法 84只雄性SD大鼠随机分为假手术组、脾切除组、辛伐他汀组、治疗组。假手术组、脾切除组用生理盐水灌胃,辛伐他汀组、治疗组用辛伐他汀灌胃10 mg/(kg.d)。脾切除组、治疗组行脾切除手术。术后第1、3、7天Y-型迷宫测试大鼠术后认知功能。结果术后第13、7、天脾切除组与其他3组Y-型迷宫实验术前与术后差值比较无统计学意义(P>0.05)。结论切脾术对大鼠术后认知功能无明显影响,辛伐他汀预处理对术后认知功能预防作用尚不清楚。

Objective To explore the influence of pretreatment with simvastatin on the postoperative cognitive function in rats with splenectomy through the Y-type maze tests. Methods 84 SD male rats were randomly divided into four groups： sham group,splenectomy group,simvastatin group and treatment group.Sham group and splenectomy group received saline gastric gavage while simvastatin group and treatment group received simvastatin gastric gavage 10 mg/（kg·d）.Splenectomy group and treatment group were performed operations of splenectomy,and at 1,3,7 days after the operation observing the postoperative cognitive function of rats through the Y-type maze tests. Results There was no difference statistically between splenectomy group of preoperation and postoperation and the other three groups（P0.05）. Conclusion Operation of splenectomy has no obvious effect on postoperative cognitive function in rats.It is not clear whether pretreatment with simvastatin can prevent POCD.